Research

Previous Peer-reviewed Publications

Efficient synthesis of D-xylo and D-ribo-phytosphingosines and their unsaturated analogs. Y. Cai, C.-C. Ling and D. R. Bundle, Carbohydr. Res., 344, 2120-2126 (2009).

Concise and Efficient Synthesis of 2-Acetamido-2-deoxy-β-d-hexopyranosides of Diverse Aminosugars from 2-Acetamido-2-deoxy-β-d-glucose. Y. Cai, C.-C. Ling and D. R. Bundle, J. Org. Chem., 74, 580-589 (2009).

Reducing Epitope Spread during Affinity Maturation of an Anti-ganglioside GD2 Antibody. J. Hu, X. Huang, C.-C. Ling, D. R. Bundle and N.-K. V. Cheung, J. Immunol., 183, 5748-5755 (2009).

Epitope Specificities of the Groups Y and W-135 Polysaccharides of Neisseria meningitides. S. L. Moore, C. Uitz, C.-C. Ling, D. R. Bundle, P. C. Fusco, and F. Michon, Clin. Vaccine Immunol., 14, 1311-1317 (2007).

Sulfatide binding properties of murine and human antiganglioside antibodies. K. Townson, K. N Greenshields, J. Veitch, D. Nicholl, M. Eckhardt, O. Galanina, N. Bovin, E. Samain, T. Antoine, D. Bundle, P. Zhang, C.-C. Ling and H. J. Willison, Glycobiology, 17, 1156 - 1166 (2007).

A general, efficient and stereospecific route to synthesize sphingosine, sphinganines and phytosphingosines and their analogs. Y. Cai, C.-C. Ling and D. R. Bundle, Org. Biomol. Chem., 4, 1140-1146 (2006).

Chemoenzymatic synthesis of GM3 and GM2 gangliosides containing a truncated ceramide functionalized for glycoconjugation and solid phase applications. S. Jacques, J. R. Rich, C.-C. Ling and D. R. Bundle, Org. Biomol. Chem., 4, 142-154 (2006).

Thio-oligosaccharide conjugate vaccines evoke antibodies specific for native antigens. D. R. Bundle, J. R. Rich, S. Jacques, H. N. Yu, M. Nitz and C.-C. Ling, Angew. Chem. Int. Ed., 44, 7725-7729 (2005).

Facile approach to 2-acetamido-2-deoxy-D-glucopyranosides via a furanosyl oxazoline. Y. Cai, C.-C. Ling and D. R. Bundle, Org. Lett., 7, 4021-4024 (2005).

A new homo-bifunctional para-nitro phenyl ester based coupling reagent for the preparation of neoglycoproteins. X. Wu, C.-C. Ling and D. R. Bundle, Org. Lett., 6, 4407-4410 (2004).

Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré Syndrome. S. M. Andersen, C.-C. Ling, P. Zhang, K. Townson, H. J. Willison and D. R. Bundle, Org. Biomol. Chem., 2, 1199-212 (2004).

Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies from autoimmune neuropathy sera. H. J. Willison, K. Townson, J. Veitch, J. Boffey, N. Isaacs, S. M. Andersen, P. Zhang, C.-C. Ling and D. R. Bundle, Brain, 127, 680-691 (2004).

Synthesis of disaccharide congeners of the Trichinella spiralis glycan and binding site mapping of two protective antibodies. P. Zhang, J. A. Appleton, C.-C. Ling and D. R. Bundle, Can. J. Chem., 80, 1141-1161, (2002).

Probing carbohydrate-antibody interactions: synthesis of three salmonella epitopes for SPR studies. H. N. Yu, C.-C. Ling and D. R. Bundle, Can. J. Chem., 80, 1131-1140 (2002).

The unique solution structure and immunochemistry of the Candida albicansb-1,2-mannopyranan cell wall antigens. M. Nitz, C.-C. Ling, A. Otter, J. E. Cutler and D. R. Bundle, J. Biol. Chem., 277: 3440-3446 (2002).

The syntheses of 6-C-alkyl derivatives of methyl a-isomaltoside for a study of the mechanism of hydrolysis by amyloglucosidase. U. Spohr, N. Le, C.-C. Ling and R. U. Lemieux, Can. J. Chem., 79, 238-255 (2001).

Efficient stereoselective synthesis of 1-thio-b-mannopyranosides. H. N. Yu, C.-C. Ling and D. R. Bundle, J. Chem. Soc. Perkin Trans. I, 832-837 (2001).

A tethered disaccharide trapped as its anti conformer calibrates the karplus relationship for 3JC-H coupling constants. S. A. Wacowich-Sgarbi, C.-C.Ling, A. Otter and D. R. Bundle, J. Am. Chem. Soc., 123, 4362-4363 (2001).

The epitope of the H-type 2 trisaccharide recognized by Erythrina corallodendron lectin. Evidence for both attractive polar and strong hydrophobic interactions for complex formation involving a lectin. R. U. Lemieux, C.-C. Ling, N. Sharon and H. Streicher, Israel J. Chem., 40, 167-176 (2000).

A practical route to 3,6-dideoxyhexoses. H. N. Yu, P. Zhang, C.-C. Ling and D. R. Bundle, Tetrahedron Asymmetry, 11, 465-479 (2000).

Amphiphilic 6-S-alkyl-6-thiocyclodextrins: unimolecular micellar and reverse micellar behaviour. J. Dey, P. Schwinte, R. Darcy, C.-C. Ling, F. Sicoli and C. Ahern, J. Chem. Soc., Perkin Trans. II, 1513-1516 (1998).

Crystal structure of the clathrate compound [dibromo-tetra(pyridine)copper(II)]pyridine – characterization by EXAFS of the pyridine desorption product. M. Selkti, C.-C. Ling and A. Navaza, J. Inclusion Phenomena, 17: 127-135 (1994).

Molecular organization in the 6-bromo-6-deoxy-cyclodextrins, formation of molecular layers and the first crystal structure of a selectively perfunctionalised b-cyclodextrin. I. Nicolis, A. W. Coleman, P. Charpin, F. Villain, P. Zhang, C.-C. Ling and C. de Rango, J. Am. Chem. Soc., 115, 11596-11597 (1993).

1st sphere coordination chemistry of modified cyclodextrins: Part II, The bis(cis-PtCl2) complex of tetradeca-O-methyl-6A,6B,6D,6E-tetra-O-nicotinoyl-a-cyclodextrin. C.-C. Ling, M. Miocque and A. W. Coleman, J. Coord. Chem., 28, 313-317 (1993).

Cyclodextrin liquid crystals: synthesis and self-organisation of amphiphilic thio-b-cyclodextrins. C.-C. Ling, R. Darcy and W. Risse, J. Chem. Soc., Chem. Commun., 438-440 (1993).

6-Hydroxyethylated 6-thiocyclodextrins, a new class of expandable host molecules. C.-C. Ling and R. Darcy, J. Chem. Soc., Chem. Commun., 203-205 (1993).

1st sphere coordination chemistry of modified cyclodextrins: the bis-CoCl2 and bis-CuBr2 complexes of 6A,6B,6D,6E-tetra-O-nicotinoyl-a-cyclodextrin. A. W. Coleman, C.-C. Ling and M. Miocque, J. Coord. Chem., 26,137-141 (1992).

Synthesis and complexation properties of a cyclodextrin siderophore analogue. A. W. Coleman, C.-C. Ling, M. Miocque, Angew. Chem. Int. Ed., 31, 1381-1383 (1992).

Multiple tritylation - A convenient route to polysubstituted cyclomaltohexaose derivatives. C.-C. Ling, A. W. Coleman and M. Miocque, Carbohydr. Res., 223, 287-291 (1992).

Self-organizing systems based on amphiphilic cyclodextrins diesters. P. Zhang, H. Parrot-Lopez, P. Tchoreloff, A. Baszkin, C.-C. Ling, C. De Rango and A. W. Coleman, J. Phys. Org. Chem., 5, 518-528 (1992).

Synthesis and properties of cyclo-a-1,4-heptamanno-2,3-epoxide. A. W. Coleman, P. Zhang, C.-C. Ling, J. Mahuteau, H. Parrot-Lopez and M. Miocque, Supramol. Chem., 1, 11-14 (1992).

Self-assembling systems of the amphiphilic cationic b-cyclodextrin 6-amino-2,3-di-O-alkylethers. H. Parrot-Lopez, C.-C. Ling, P. Zhang, A. Baszkin, G. Albrecht, C. de Rango and A. W. Coleman, J. Am. Chem. Soc., 114, 5479-5480 (1992).

The use of chlorodimethylthexylsilane for protecting the hydroxyl groups in cyclomaltoheptaose (b-cyclodextrin). A. W. Coleman, P. Zhang, C.-C. Ling and H. Parrot-Lopez, Carbohydr. Res., 224, 307-309 (1992).

The first selective per-tosylation of the secondary OH-2 of b-cyclodextrin, A. W. Coleman, P. Zhang, H. Parrot-Lopez, C.-C. Ling, M. Miocque and L. Mascrier, Tetrahedron Lett., 32, 3997-3998 (1991).

Formation of amphiphilic cyclodextrins via hydrophobic esterification at the secondary hydroxyl face. P. Zhang, C.-C. Ling, A. W. Coleman, H. Parrot-Lopez and H. Galons, Tetrahedron Lett., 32, 2769-2770 (1991).