Independent Poster Presentations

Supermolecular Display of Carbohydrate Arrays Reveals Unprecedented Binding To Bacterial Toxins. P. Zhang, E. Paszkiewicz, J. Sadowsk, P. Kitov, D. Bundle and C.-C. Ling, Gordon Research Conference - Carbohydrates, Mount Snow Resort, Vermont, USA, June 14-19, 2015.Supermolecular Display of Carbohydrate Arrays Reveals Unprecedented Binding To Bacterial Toxins. P. Zhang, E. Paszkiewicz, J. Sadowsk, P. Kitov, D. Bundle and C.-C. Ling, Gordon Research Conference - Carbohydrates, Mount Snow Resort, Vermont, USA, June 14-19, 2015.

Progress Towards the Synthesis of 6-Deoxy-?-D-ido-heptopyranosides. P. Zhang, R. Hevey, C.-C. Ling, 11th National Carbohydrate Symposium, Banff, Alberta, May 2015.

The Dimerization of 6A,6B,6D,6E-Tetrathiol of a-Cyclodextrin. A. Wang, W. Li, P. Zhang and C.-C. Ling, 11th National Carbohydrate Symposium, Banff, Alberta, May 2015.

Supermolecular Display of Carbohydrate Arrays Reveals Unprecedented Binding to Bacterial Toxins. P. Zhang, E. Paszkiewicz, Q. Wang, J. Sadowska, P. Kitov, D. R. Bundle and C.-C. Ling, 11th National Carbohydrate Symposium, Banff, Alberta, May 2015.

Development of Per-6-Thiol-b-Cyclodextrin-Based Biosensors for Detecting Exogenous Cancer Biomarker. P.-L. Champagne, P. Zhang, C.-C. Ling, 11th National Carbohydrate Symposium, Banff, Alberta, May 2015.

Progress Towards a Novel Synthesis of KDO and Analogues. M. Vennampalli, M. François-Heude, C.-C. Ling, 11th National Carbohydrate Symposium, Banff, Alberta, May 2015.

Chemical Synthesis of Carbohydrate-based Inhibitors to Interfere with the Biosynthesis of Chondroitin Sulfate Proteoglycans. P. Zhang, M. François-Heude, T. Chen, A. Wang, M. Keough, J. Rogers, V. W. Yong and C.-C. Ling, 2014 Alberta EndMS Retreat, Banff, Alberta, Canada. Sept. 26-27, 2014.

Large-Scale Synthesis of Amphiphilic Cyclodextrin-Based Glycodendrimers for Delivery of Anticancer Drugs. Q. Wang, J. Gu, P. Zhang, C.-C. Ling, 97th CSC Conference, Vancouver, BC, June 1-4, 2014.

Chemoenzymatic Synthesis of PK-trisaccharide-based Multivalent Ligands to Interact with Shiga-like Toxins. P. Zhang, E. Paszkiewicz, Q. Wang, J. Sadowska, P. Kitov, D.R.Bundle, C.-C. Ling, 97th CSC Conference, CVancouver, BC, June 1-4, 2014.

Large-Scale Synthesis of Amphiphilic Cyclodextrin-Based Glycodendrimers for Delivery of Anticancer Drugs. Q. Wang, J. Gu, P. Zhang, C.-C. Ling, 10th National Carbohydrate Symposium, Canmore, Alberta, May 2014.

Synthesis of Covalently Linked NBD-Cyclodextrin Fluorophores Used as Probes to Study Drug Delivery. T. Chen, P. Zhang, J. Gu and C.-C. Ling, 10th National Carbohydrate Symposium, Canmore, Alberta, May 2014.

Progress Towards the 6-Homologation to Obtain 6-Deoxy-beta-D-ido-heptopyranosides. P. Zhang, R. Hevey and C.-C. Ling, 10th National Carbohydrate Symposium, Canmore, Alberta, May 2014. –

Controlled Acid-Mediated Regioselective O-Desilylations for Multi-Functionalization of Cyclodextrins. J. Gu, T. Chen, P. Zhang and C.-C. Ling, 10th National Carbohydrate Symposium, Canmore, Alberta, May 2014.

Synthesis of Amphiphilic Cyclodextrin-Pk-Trisaccharide Conjugates for Use to Study Carbohydrate-Toxin Interaction. P. Zhang, E. Paszkiewicz, Q. Wang, J. Sadowska, P. Kitov, D. Bundle and C.-C. Ling, 10th National Carbohydrate Symposium, Canmore, Alberta, May 2014.

Regio- and Chemoselective O-desilylation of Cyclodextrins. R. Ghosh, A. X. Wang, P. Zhang and C.-C. Ling, 3rd European Conference on Cyclodextrins, Antalya, Turkey, October 2-4, 2013.

Sugar-Coated Non-ionic ‘Nanocapsule’ for Improved Drug Delivery. L. Cui, C. Zhang, R. Ghosh, P. Zhang and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

Inhibiting Clostridium difficile Toxins Using Synthetic Ligands. P. Zhang, K. Ng and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

DIBAL-H Mediated O-Desilylation with Highly Sterically Hindered Cyclodextrin Subtrates. C. Hennigan, R. Ghosh and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

Synthetic Efforts Towards α-Kdo Glycosides. R. Maillet and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

Mechanism and synthetic utility of the conversion of 2,3-di-O-sulfonyl-ß-D-galactopyranosides to generate ß-D-idopyranosides. R. Hevey and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

Inhibiting Clostridium difficile Toxins Using Synthetic Ligands. P. Zhang, K. Ng and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

SThe Dimerization of 6A,6B,6D,6E-Tetrathiol of α-Cyclodextrin. W. Li, T. Chen, P. Zhang, and C.-C. Ling, 9th National Carbohydrate Symposium, Banff, Alberta, May 2013.

Sugar-Coated Non-ionic ‘Nanocapsule’ for Improved Drug Delivery. L. Cui, C. Zhang, R. Ghosh, P. Zhang and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Development of an Efficient Synthesis for α-Kdo Glycosides. R. Maillet and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Concise Synthesis of Biotin Appended Cyclodextrin Based Glycodendrimer as a Diagnostic Tool. R. Ghosh, A. Wang and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Synthesis of a New Generation of Carbohydrate-Amino Acid Conjugates to Inhibit C. difficile Toxin A. P. Zhang, T. Chen, R. Hevey, A. Elhawiet, J. Sadowska, J. Klassen, D. R. Bundle, K. Ng and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Efficient Synthesis of a Novel α-Cyclodextrin-based Capsule. A. Wang, W. Li and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Synthesis of Cyclodextrin Derivatives via Copper-Catalyzed Huisgen 1,3-Dipolar Cycloaddition for Liquid Crystal Studies. S. Ward and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

Mechanistic interrogation of a key step involved in a novel route to obtaining orthogonally-protected idopyranosides. R. Hevey and C.-C. Ling, 8th National Carbohydrate Symposium, Banff, Alberta, May 2012.

An Efficient One-Pot Synthesis for 1,2-disubstituted Tetrazoles from Amide Precursors. R. Maillet and C.-C. Ling, 95th CSC Conference, Calgary, Alberta, May 2012.

Characterization of Carbohydrate Binding Domain of Clostridium diffcile Toxin A. P. Zhang, L. Eugenio, K. K. –S. Ng and C.-C. Ling, 95th CSC Conference, Calgary, Alberta, May 2012.

Efficient Synthesis of a Novel ß-Cyclodextrin-based Capsule. A. Wang, W. Li and C.-C. Ling, 95th CSC Conference, Calgary, Alberta, May 2012.

Synthesis of Cyclodextrin Derivatives via Copper-catalyzed Huisgen 1,3-Dipolar Cycloaddition for Liquid Crystal Studies. S. Ward and C.-C. Ling, The 7th Banff Symposium on Organic Chemistry (BSOC), Banff, Alberta, Nov. 2011.

A novel route to ido-pyranosides and its application in the synthesis of 6-deoxy-ß-D-heptopyranosides from Campylobacter jejuni capsular polysaccharide. R. Hevey and C.-C. Ling, Eurocarb16, Sorrento, Italy, July 2011.

Rational Design and Synthesis of a New Generation of Carbohydrate-based Inhibitors for C. difficile Toxin A. P. Zhang, J. Sadowska, D. Bundle, K. Ng and C.-C. Ling, 7th National Carbohydrate Symposium, Banff, Alberta, May 2011.

A new approach to orthogonally protected ido-hexoses. R. Hevey and C.-C. Ling, 7th National Carbohydrate Symposium, Banff, Alberta, May 2011.

Concise Synthesis and Self-assembling Properties of Cyclodextrin-Based Glycoclusters for Studying Carbohydrate-Protein Interaction. R. Ghosh, M. Bhowmick, S. Trudel and C.-C. Ling, 7th National Carbohydrate Symposium, Banff, Alberta, May 2011.

An Efficient One-pot Synthesis for 1,5-Disubstituted Tetrazoles from Amide Precursors. R. Maillet and C.-C. Ling, 7th National Carbohydrate Symposium, Banff, Alberta, May 2011.

Synthesis of Cyclodextrin Based Glycoclusters to Inhibit Bacterial Colonization. M. J. Bosch, S. M. Ward, C.-C. Ling. 2nd Western Canadian Medicinal Chemistry Workshop, Saskatoon, Saskatchewan, Sep. 24-26, 2010. – Best Poster Award

Synthesis of carbohydrate-based analogs for characterization of the binding site of Clostridium difficile toxin A. R. Hevey*, P. Zhang, L. Eugenio, K. Ng, C.-C. Ling, 25rd International Carbohydrate Symposium, Tokyo, August 1-6, 2010.

Synthesis of Novel Cyclodextrin Derivatives For Liquid Crystal Studies. S. Ward*, C.-C. Ling, 93st CSC Conference, Toronto, May 31-Jun 4, 2010.

Characterization of Carbohydrate Binding Site of C. difficile Toxins Using Synthetic Carbohydrates. C.-C. Ling, P. Zhang, K. Ng, 93rd CSC Conference 2010, Toronto, May 31, 2010.

A Synthesis for Tetrazole Functionality from Amide Precursor. *R. Maillet, C.-C. Ling, Western Canadian Undergraduate Chemsitry Conference 2010, Lethbridge, Alberta, May 6-8, 2010. -Best Poster Award

Synthesis of Cyclodextrin-based Glycoclusters for Potential Anti-bacterial Activities, A. Wang*, Zia-Ullah, C.-C. Ling, 6th National Carbohydrate Symposium, Banff, Alberta, May 6-8, 2010.

Convenient Conversion of D-GlcNAc to D-GalNAc and Derivatives, J. Feng*, C.-C. Ling, 6th National Carbohydrate Symposium, Banff, Alberta, May 6-8, 2010 .

Rational Design and Synthesis of a New Generation of Carbohydrate-based Inhibitors for C. difficile Toxin A, P. Zhang*, E. Kitova, J. Klassen, K. Ng, C.-C. Ling, 6th National CarbohydrateSymposium, Banff, Alberta, May 6-8, 2010.

Probing CST-II’s Recognition Domain for Acceptor Substrates in α(2,8)-Sialylations, W. Li*, P. Zhang, A. J. Zuccolo, R. B Zheng, C.-C. Ling, 6th National Carbohydrate Symposium, Banff, Alberta, May 6-8, 2010.

Stereoselective Synthesis of KDO Glycosides Using 1-C-Aryl Glycals, Y. Qian*, J. Feng, C.-C. Ling, 6th National Carbohydrate Symposium, Banff, Alberta, May 6-8, 2010.

Synthesis of a unique 6-deoxy-D-ido-heptopyranose unit from the capsular polysaccharide component of Campylobacter jejuni, R. Hevey*, C.-C. Ling, 6th National Carbohydrate Symposium, Banff, Alberta, May 6-8, 2010.

The Synthesis of 2'-FucLac and LacNAc-LeX to Probe as Competitive Inhibitors against Clostridium difficile Toxins, R. Hevey*, P. Zhang, K. Ng, C.-C. Ling, Banff Symposium on Organic Chemistry 2009, Banff, Alberta, May 6-8, 2010.

Non-protein dependent, direct membrane binding leads to cell surface lipid sorting and Syk kinase activation in dendritic cells. G. Ng,* K. Sharma, S. M. Ward, M. D. Desrosiers, L. A. Stephens, W. M. Schoel, T. Li, L. Lanier, C. A. Lowell, C.-C. Ling, M. W. Amrein, and Y. Shi, AAI Immunology 2009 Conference; Seattle, Washington, May 8-12, 2009.

The synthesis of 2'-FucLac and LacNAc-LeX to probe as competitive inhibitors against Clostridium difficile toxins." R. Hevey,* P. Zhang, K. Ng and C.-C. Ling. Banff Symposium on Organic Chemistry 2009, Banff, Alberta. Oct 29 – Nov 1 2009.

The Synthesis of LeA-LacNAc Pentasaccharide as a Ligand for Clostridium difficile TcdA Toxin. P. Zhang,* K. Ng and C.-C. Ling, 92st CSC Conference; Hamilton; Ontario, May 29-Jun 3, 2009.

Chemoenzymatic Synthesis of S-linked α(2,8)-Oligosialic Acids. W. Li,* R. B. Zheng and C.-C. Ling, 92st CSC Conference; Hamilton; Ontario, May 29-Jun 3, 2009.

New Developments in Cyclodextrin Chemistry leading to Novel Architectures. G. K. Rawal* and C.-C. Ling, 92st CSC Conference; Hamilton; Ontario, May 29-Jun 3, 2009.

Synthesis of Forssman Antigen Analog. J. Feng* and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

The first O-glycoside with Its Anomeric Proton Resonating at 2.88 PPM. Sandra Ward,* P. Zhang and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

A Novel Synthesis of Fluorescent Pentaene Motif. A. J. Zuccolo,* T. A. L. Kubik and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

The Synthesis of Lea-LacNAc and Lex-LacNAc Pentasaccharides and Lea-LeX Hexasaccharide as Ligands for Clostridium difficile Toxins. P. Zhang,* K. Ng and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

Adding New Dimensions to Cyclodextrin Chemistry: Modification and Novel Architectures. G. K. Rawal* and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

The Efficient Synthesis of KDO and the Development of KDO Glycoside Syntheses Using a p-Methoxyphenyl Masked Donor. Y. Qian,* J. Feng, C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

The True Identity of the Leading Binder to Clostridium difficile Toxin A: Chemical Elucidation and Total Synthesis, P. Zhang,* K. Ng, C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

CST-II Mediated α(2,8)-Sialylations Using S-linked Sialosides As Substrates. W. Li,* R. B. Zheng and C.-C. Ling, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

The Development of a Bottom-up Synthesis of α(2,8)-Oligosialosides Leading to an Octamer. C.-C. Ling,* P. Zhang, A. J. Zuccolo, W. Li, R. B. Zheng, 5th National Carbohydrate Symposium, Banff, Alberta; May 14-16, 2009.

An Efficient Chemoenzymatic Synthesis of α(2,8)-Oligosialic Acids. A. J. Zuccolo,* W. Li, R. B. Zheng, C.-C. Ling. 24th International Carbohydrate Symposium; Oslo, Norway, Jul 27 - Aug 1, 2008.

An Efficient Chemoenzymatic Synthesis of α(2,8)-Oligosialic Acids. A. J. Zuccolo,* R. B. Zheng and C.-C. Ling. 91st CSC Conference; Edmonton; Alberta, May 24-28, 2008.

Synthesis of Pentaene Fatty Acids as Fluorophores. T. A. L. Kubik,* A. J. Zuccolo, J. Key, C. W. Cairo, and C.-C. Ling. 4th National Carbohydrate Sympossium; Banff, Alberta, May 1-3, 2008.

The Synthesis of LeA-LacNAc Pentasaccharide as a Ligand for Clostridium Difficile TcdA Toxin. P. Zhang,* K. Ng, and C.-C. Ling. 4th National Carbohydrate Sympossium; Banff, Alberta, May 1-3, 2008.

An Efficient Chemoenzymatic Synthesis of α(2,8)-Oligosialic Acids. A. J. Zuccolo,* R. B. Zheng and C.-C. Ling. 4th National Carbohydrate Sympossium; Banff, Alberta, May 1-3, 2008.

Non-protein dependent, direct membrane binding leads to cell surface lipid sorting and Syk kinase activation in dendritic cells. G. Ng, K. Sharma, S. M. Ward, M. D. Desrosiers, L. A. Stephens, W. M. Schoel, T. Li, L. Lanier, C. A. Lowell, C.-C. Ling, M. W. Amrein, and Y. Shi, The Calvin, Phoebe, and Joan Snyder Institute of Infection, Immunity and Inflammation Research Symposium; Calgary, Alberta, Sep 29, 2008.

Receptor independent, direct membrane binding leads to cell surface lipid sorting and dendritic cell activation. G. Ng, K. Sharma, S. M. Ward, M. D. Desrosiers, L. A. Stephens, W. M. Schoel, T. Li, L. Lanier, C. A. Lowell, C.-C. Ling, M. W. Amrein, and Y. Shi, USRP in Health and Wellness Student Symposium 2008; Calgary, Alberta, Sep 18, 2008.