Inhibition of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination.
A synthetic peracetylated 4-fluoro-glucosamine has been shown to inhibit the biosynthesis of chondroitin sulfate proteoglycans (CSPGs), which could provide a useful strategy to promote repair in multiple sclerosis and other neurological disorders, by reducing deposition of CSPGs into the lesion microenvironment. See: M. B. Keough, J. A. Rogers, P. Zhang, S. K. Jensen, E. L. Stephenson, T. Chen, M. G. Hurlbert, L. W. Lau, K. S. Rawji, J. R. Plemel, M. Koch, C.-C. Ling, V. W. Yong, Nat. Commun. , 7, 11312. DOI: 10.1038/ncomms11312.